AIDS-Myelopathy
Identifieur interne : 001B27 ( Main/Exploration ); précédent : 001B26; suivant : 001B28AIDS-Myelopathy
Auteurs : M. Bergmann [Allemagne] ; F. Gullotta [Allemagne] ; K. Kuchelmeister [Allemagne] ; Tina Masini [Italie] ; G. Angeli [Italie]Source :
- Pathology - Research and Practice [ 0344-0338 ] ; 1993.
English descriptors
- KwdEn :
- Teeft :
- Acta neuropathol, Arch neurol, Axon, Axonal spheroids, Capsula interna, Cerebrospinal fluid, Cervical cord, Chronic myelopathy, Clinical aids, Clinical data, Clinical neurology, Cord, Degeneration, Gait disturbance, General autopsy, Gracile tract degeneration, Human immunodeficiency virus, Human immunodeficiency virus infection, Human pathol, Immunodeficiency, Immunodeficiency syndrome, Incomplete tissue sampling, Intravascular coagulation, Lateral, Lateral columns, Lesion, Long tracts, Macrophage, Minor degree, Morphological findings, Multinucleated, Multinucleated cells, Myelopathy, Nervous system, Neurofilament protein, Neurogenic bladder, Neurol, Neurological symptoms, Neurology, Neuropathol, Neuropathol appl neurobiol, Neuropathological study, Neuropathy, Oral thrush, Paraparesis, Pathogenesis, Playa role, Positive reaction, Posterior columns, Risk factors, Sensory neuropathy, Spastic paraparesis, Spinal, Spinal cord, Spinal cord lesions, Spinal cord pathology, Spinal cord symptoms, Spinal cords, Spinal roots, Syndrome, Vacuolar, Vacuolar changes, Vacuolar degeneration, Vacuolar myelopathy, Vacuolation, Vacuole, Wallerian degeneration, White matter.
Abstract
Summary: Vacuolar myelopathy belongs to the AIDS-associated diseases. It is characterized by vacuolation and infiltration of the long tracts of the spinal cord by macrophages. The clinical and morphological findings of 8 AIDS-patients with vacuolar myelopathy are reported here. The syndrome developed during the final stages of AIDS and was associated with HIV-encephalopathy in 5 cases. The vacuoles were mainly due to intramyelinic swelling and vacuolation. Vacuolated macrophages and axons contributed only to a minor degree. In one case only, HIV-antigens were detected immunohistochemically. The results are discussed in the light of modern pathogenetical concepts of HIV-related diseases.
Url:
DOI: 10.1016/S0344-0338(11)80117-2
Affiliations:
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Le document en format XML
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<keywords scheme="Teeft" xml:lang="en"><term>Acta neuropathol</term>
<term>Arch neurol</term>
<term>Axon</term>
<term>Axonal spheroids</term>
<term>Capsula interna</term>
<term>Cerebrospinal fluid</term>
<term>Cervical cord</term>
<term>Chronic myelopathy</term>
<term>Clinical aids</term>
<term>Clinical data</term>
<term>Clinical neurology</term>
<term>Cord</term>
<term>Degeneration</term>
<term>Gait disturbance</term>
<term>General autopsy</term>
<term>Gracile tract degeneration</term>
<term>Human immunodeficiency virus</term>
<term>Human immunodeficiency virus infection</term>
<term>Human pathol</term>
<term>Immunodeficiency</term>
<term>Immunodeficiency syndrome</term>
<term>Incomplete tissue sampling</term>
<term>Intravascular coagulation</term>
<term>Lateral</term>
<term>Lateral columns</term>
<term>Lesion</term>
<term>Long tracts</term>
<term>Macrophage</term>
<term>Minor degree</term>
<term>Morphological findings</term>
<term>Multinucleated</term>
<term>Multinucleated cells</term>
<term>Myelopathy</term>
<term>Nervous system</term>
<term>Neurofilament protein</term>
<term>Neurogenic bladder</term>
<term>Neurol</term>
<term>Neurological symptoms</term>
<term>Neurology</term>
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<term>Neuropathy</term>
<term>Oral thrush</term>
<term>Paraparesis</term>
<term>Pathogenesis</term>
<term>Playa role</term>
<term>Positive reaction</term>
<term>Posterior columns</term>
<term>Risk factors</term>
<term>Sensory neuropathy</term>
<term>Spastic paraparesis</term>
<term>Spinal</term>
<term>Spinal cord</term>
<term>Spinal cord lesions</term>
<term>Spinal cord pathology</term>
<term>Spinal cord symptoms</term>
<term>Spinal cords</term>
<term>Spinal roots</term>
<term>Syndrome</term>
<term>Vacuolar</term>
<term>Vacuolar changes</term>
<term>Vacuolar degeneration</term>
<term>Vacuolar myelopathy</term>
<term>Vacuolation</term>
<term>Vacuole</term>
<term>Wallerian degeneration</term>
<term>White matter</term>
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<front><div type="abstract" xml:lang="en">Summary: Vacuolar myelopathy belongs to the AIDS-associated diseases. It is characterized by vacuolation and infiltration of the long tracts of the spinal cord by macrophages. The clinical and morphological findings of 8 AIDS-patients with vacuolar myelopathy are reported here. The syndrome developed during the final stages of AIDS and was associated with HIV-encephalopathy in 5 cases. The vacuoles were mainly due to intramyelinic swelling and vacuolation. Vacuolated macrophages and axons contributed only to a minor degree. In one case only, HIV-antigens were detected immunohistochemically. The results are discussed in the light of modern pathogenetical concepts of HIV-related diseases.</div>
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