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AIDS-Myelopathy

Identifieur interne : 001B27 ( Main/Exploration ); précédent : 001B26; suivant : 001B28

AIDS-Myelopathy

Auteurs : M. Bergmann [Allemagne] ; F. Gullotta [Allemagne] ; K. Kuchelmeister [Allemagne] ; Tina Masini [Italie] ; G. Angeli [Italie]

Source :

RBID : ISTEX:169A391BA17F1387903D0BA244539911B976241F

English descriptors

Abstract

Summary: Vacuolar myelopathy belongs to the AIDS-associated diseases. It is characterized by vacuolation and infiltration of the long tracts of the spinal cord by macrophages. The clinical and morphological findings of 8 AIDS-patients with vacuolar myelopathy are reported here. The syndrome developed during the final stages of AIDS and was associated with HIV-encephalopathy in 5 cases. The vacuoles were mainly due to intramyelinic swelling and vacuolation. Vacuolated macrophages and axons contributed only to a minor degree. In one case only, HIV-antigens were detected immunohistochemically. The results are discussed in the light of modern pathogenetical concepts of HIV-related diseases.

Url:
DOI: 10.1016/S0344-0338(11)80117-2


Affiliations:


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Le document en format XML

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<term>AIDS related diseases</term>
<term>HIV-encephalopathy</term>
<term>Vacuolar leucoencephalopathy</term>
<term>Vacuolar myelopathy</term>
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<keywords scheme="Teeft" xml:lang="en">
<term>Acta neuropathol</term>
<term>Arch neurol</term>
<term>Axon</term>
<term>Axonal spheroids</term>
<term>Capsula interna</term>
<term>Cerebrospinal fluid</term>
<term>Cervical cord</term>
<term>Chronic myelopathy</term>
<term>Clinical aids</term>
<term>Clinical data</term>
<term>Clinical neurology</term>
<term>Cord</term>
<term>Degeneration</term>
<term>Gait disturbance</term>
<term>General autopsy</term>
<term>Gracile tract degeneration</term>
<term>Human immunodeficiency virus</term>
<term>Human immunodeficiency virus infection</term>
<term>Human pathol</term>
<term>Immunodeficiency</term>
<term>Immunodeficiency syndrome</term>
<term>Incomplete tissue sampling</term>
<term>Intravascular coagulation</term>
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<term>Lateral columns</term>
<term>Lesion</term>
<term>Long tracts</term>
<term>Macrophage</term>
<term>Minor degree</term>
<term>Morphological findings</term>
<term>Multinucleated</term>
<term>Multinucleated cells</term>
<term>Myelopathy</term>
<term>Nervous system</term>
<term>Neurofilament protein</term>
<term>Neurogenic bladder</term>
<term>Neurol</term>
<term>Neurological symptoms</term>
<term>Neurology</term>
<term>Neuropathol</term>
<term>Neuropathol appl neurobiol</term>
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<term>Pathogenesis</term>
<term>Playa role</term>
<term>Positive reaction</term>
<term>Posterior columns</term>
<term>Risk factors</term>
<term>Sensory neuropathy</term>
<term>Spastic paraparesis</term>
<term>Spinal</term>
<term>Spinal cord</term>
<term>Spinal cord lesions</term>
<term>Spinal cord pathology</term>
<term>Spinal cord symptoms</term>
<term>Spinal cords</term>
<term>Spinal roots</term>
<term>Syndrome</term>
<term>Vacuolar</term>
<term>Vacuolar changes</term>
<term>Vacuolar degeneration</term>
<term>Vacuolar myelopathy</term>
<term>Vacuolation</term>
<term>Vacuole</term>
<term>Wallerian degeneration</term>
<term>White matter</term>
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<div type="abstract" xml:lang="en">Summary: Vacuolar myelopathy belongs to the AIDS-associated diseases. It is characterized by vacuolation and infiltration of the long tracts of the spinal cord by macrophages. The clinical and morphological findings of 8 AIDS-patients with vacuolar myelopathy are reported here. The syndrome developed during the final stages of AIDS and was associated with HIV-encephalopathy in 5 cases. The vacuoles were mainly due to intramyelinic swelling and vacuolation. Vacuolated macrophages and axons contributed only to a minor degree. In one case only, HIV-antigens were detected immunohistochemically. The results are discussed in the light of modern pathogenetical concepts of HIV-related diseases.</div>
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